GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4285028 | 1 | rs4285028 | chr3:121660664 | SLC15A2 | chr3:121613171-121663034:+ | 0.23 | 4.51 | 8.22E-6 | Multiple sclerosis |
| THCA | cis | rs11734488 | 1 | rs4285139 | chr4:139120053 | SLC7A11 | chr4:139085248-139163503:- | 0.22 | 4.44 | 1.12E-5 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs10043228 | 1 | rs4286716 | chr5:115519697 | COMMD10 | chr5:115420727-115628978:+ | -0.47 | -6.01 | 3.78E-9 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs1398024 | 1 | rs4287250 | chr10:23664391 | C10orf67 | chr10:23605521-23633772:- | -0.23 | -4.51 | 8.16E-6 | Crohn's disease and sarcoidosis (combined) |
| THCA | cis | rs6748734 | 1 | rs4293565 | chr2:241834770 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.1 | 2.22E-9 | Urinary metabolites |
| THCA | cis | rs4294134 | 1 | rs4294134 | chr7:135293128 | PL-5283 | chr7:135347221-135378160:+ | 0.68 | 15.63 | 8.49E-45 | Paget's disease |
| THCA | cis | rs4294134 | 1 | rs4294134 | chr7:135293128 | SLC13A4 | chr7:135365993-135412933:- | -0.68 | -11.27 | 2.82E-26 | Paget's disease |
| THCA | cis | rs12196860 | 1 | rs4295483 | chr6:55965456 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs12196860 | 1 | rs4295484 | chr6:55965646 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs6494537 | 1 | rs429657 | chr15:65813764 | DPP8 | chr15:65737999-65810035:- | 0.09 | 3.7 | 0.000244 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs429657 | chr15:65813764 | SLC24A1 | chr15:65903704-65953256:+ | 0.15 | 3.63 | 0.000318 | Mean corpuscular hemoglobin |
| THCA | cis | rs2149423 | 1 | rs4297570 | chr13:36755179 | SOHLH2 | chr13:36742347-36871992:- | -0.39 | -6.67 | 7.2E-11 | Glucose homeostasis traits |
| THCA | cis | rs4299518 | 1 | rs4299518 | chr3:45809273 | LARS2 | chr3:45430075-45590328:+ | 0.12 | 3.56 | 0.000412 | Hirschsprung disease |
| THCA | cis | rs4299518 | 1 | rs4299518 | chr3:45809273 | SACM1L | chr3:45730754-45786900:+ | 0.13 | 4.39 | 1.37E-5 | Hirschsprung disease |
| THCA | cis | rs1926657 | 1 | rs4303338 | chr13:95876101 | ABCC4 | chr13:95672084-95953687:- | 0.18 | 3.51 | 0.000499 | Breast cancer |